Hope-Gill B, Goepel J R, Collin R C
Chesterfield Royal Hospital, Department of Haematology, Calow, UK.
J Clin Pathol. 1998 Apr;51(4):340-2. doi: 10.1136/jcp.51.4.340.
A 72 year old man was diagnosed with chronic myelomonocytic leukaemia (CMML) according to the FAB group classification. He presented with symptoms of anaemia, urinary frequency, hesitancy, and nocturia. He was later admitted with acute urinary retention and acute renal failure, which resolved with treatment. A transurethral resection of the prostate was performed. Histological examination showed fibromuscular hyperplasia with dense infiltration by myelomonocytes which stained positively with chloroacetate esterase; immunohistochemical staining was positive for lysozyme, CD43, CD45, and CD68. Following treatment with oral etoposide he transformed to acute myeloid leukaemia and eventually died. Myelomonocytic infiltration of the prostate has not been reported before. This case extends the spectrum of disease previously recognised in CMML.
一名72岁男性根据FAB组分类被诊断为慢性粒单核细胞白血病（CMML）。他出现了贫血、尿频、排尿犹豫和夜尿等症状。后来他因急性尿潴留和急性肾衰竭入院，经治疗后病情缓解。进行了经尿道前列腺切除术。组织学检查显示纤维肌增生，有髓单核细胞密集浸润，氯乙酸酯酶染色呈阳性；免疫组化染色显示溶菌酶、CD43、CD45和CD68呈阳性。口服依托泊苷治疗后，他转变为急性髓系白血病，最终死亡。前列腺的髓单核细胞浸润此前未见报道。该病例扩展了CMML先前公认的疾病谱。
