O'Connor T A, Grueber R
Division of Neonatology, Children's Hospital, University of Missouri-Columbia, USA.
J Perinatol. 1998 May-Jun;18(3):189-92.
To determine the efficacy of transcutaneous carbon dioxide tension measurement during high-risk neonatal transport.
This was a prospective, randomized comparative study. Infants transported from hospitals more than 30 miles away from our center and who required respiratory intervention were enrolled. Alternating transports used a transcutaneous CO2/O2 monitor. Ventilation parameters and end transport blood gas values served as primary endpoints for the study.
Infants with transcutaneous carbon dioxide tension monitoring were more likely to have decreased ventilator peak pressures during transport than neonates not monitored (-1.5 cm H2O vs + 0.6 cm H2O; p = 0.04). Monitored neonates were more likely to arrive at the tertiary center with a more normal pH and a CO2 tension between 35 and 45 mm Hg (4.7 to 6.0 kPa) than nonmonitored infants (p = 0.03 and p = 0.01, respectively). The stabilization times before transport were not significantly prolonged by the use of the transcutaneous monitor.
Transcutaneous monitoring of CO2 tension improves short-term respiratory outcome in neonates receiving mechanical ventilation during transport.
确定高危新生儿转运期间经皮二氧化碳分压测量的有效性。
这是一项前瞻性随机对照研究。纳入从距离我们中心30多英里以外医院转运且需要呼吸干预的婴儿。交替转运使用经皮二氧化碳/氧气监测仪。通气参数和转运结束时的血气值作为研究的主要终点。
与未监测的新生儿相比，经皮二氧化碳分压监测的婴儿在转运期间呼吸机峰值压力更有可能降低（-1.5 cm H2O对+0.6 cm H2O；p = 0.04）。与未监测的婴儿相比，监测的新生儿到达三级中心时更有可能具有更正常的pH值和35至45 mmHg（4.7至6.0 kPa）之间的二氧化碳分压（分别为p = 0.03和p = 0.01）。使用经皮监测仪并未显著延长转运前的稳定时间。
经皮二氧化碳分压监测可改善转运期间接受机械通气的新生儿的短期呼吸结局。
