Chávez E, Sarmiento F, López M, Kakarieka E, Vial M T, Gotteland M
Departamento de Anatomía Patológica, Hospital Clínico San Borja-Arriarán.
Rev Med Chil. 1998 Feb;126(2):139-43.
Helicobacter pylori produces a gastric mucosal inflammation characterized by neutrophil infiltration, due to the liberation of interleukin-8.
To measure interleukin-8 levels in gastric mucosa samples from children colonized by H. pylori.
Thirty one children that required an upper gastrointestinal endoscopy for diagnostic purpose were studied. Antral biopsies were obtained for pathological study, H. pylori detection using CLO-test and interleukin-8 determination by ELISA.
Nine children were not infected with H. pylori. Of these, six had a pathologically normal gastric mucosa and three had a mild chronic gastritis. Twenty two children were infected by H. pylori and all had a chronic gastritis with activity signs in 13. Mucosal interleukin-8 was higher in infected than in non infected children (59.7 (range 6.1-379.7) and 15.8 (range 3.9-104.1) pg/mg respectively p = 0.029). Colonized children with an active chronic gastritis had higher interleukin-8 levels than those with inactive gastritis (84.4 (range 33.3-379.0) and 26.8 (range 6.1-372.6) pg/ml respectively p = 0.04).
Stomach colonization by H. pylori is associated with higher mucosal levels of interleukin-8. This phenomenon probably plays a role in the genesis and intensity of gastric mucosal inflammation in children.
幽门螺杆菌可引发以中性粒细胞浸润为特征的胃黏膜炎症，这是由于白细胞介素-8的释放所致。
检测幽门螺杆菌定植儿童胃黏膜样本中的白细胞介素-8水平。
对31名因诊断目的需要进行上消化道内镜检查的儿童进行研究。获取胃窦活检组织用于病理研究、采用CLO检测法检测幽门螺杆菌以及通过酶联免疫吸附测定法测定白细胞介素-8。
9名儿童未感染幽门螺杆菌。其中，6名儿童胃黏膜病理正常，3名儿童患有轻度慢性胃炎。22名儿童感染了幽门螺杆菌，所有患儿均患有慢性胃炎，其中13名有活动迹象。感染儿童的黏膜白细胞介素-8水平高于未感染儿童（分别为59.7（范围6.1 - 379.7）和15.8（范围3.9 - 104.1）pg/mg，p = 0.029）。患有活动性慢性胃炎的定植儿童白细胞介素-8水平高于非活动性胃炎患儿（分别为84.4（范围33.3 - 379.0）和26.8（范围6.1 - 372.6）pg/ml，p = 0.04）。
幽门螺杆菌在胃内定植与黏膜白细胞介素-8水平升高有关。这种现象可能在儿童胃黏膜炎症的发生和严重程度中起作用。
