Stratford T R, Swanson C J, Kelley A
Department of Psychiatry, University of Wisconsin-Madison Medical School 53719, USA.
Behav Brain Res. 1998 Jun;93(1-2):43-50. doi: 10.1016/s0166-4328(97)00140-x.
Blockade of non-N-methyl-D-aspartic acid (NMDA) ionotropic glutamate receptors in the nucleus accumbens shell (AcbSh) with 6,7-dinitroquinoxaline-2,3-dione (DNQX) elicits intense feeding in satiated rats. In order to determine whether or not this feeding is part of a general behavioral activation, we observed the effect of intra-AcbSh DNQX injections on intake of solid food, liquid food, and water, and on gnawing behavior. In addition, we investigated the possibility that activation of a subset of these receptors with (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) could suppress feeding. DNQX significantly increased intake of solid and liquid food, but did not significantly affect water intake or gnawing behavior. Furthermore, injections of AMPA into the AcbSh suppressed deprivation-induced feeding and intake of a palatable 5% sucrose solution without affecting water intake in water-deprived rats. Taken together, these data suggest that DNQX is acting on a system specifically involved with the regulation of food intake.
用6,7-二硝基喹喔啉-2,3-二酮（DNQX）阻断伏隔核壳（AcbSh）中的非N-甲基-D-天冬氨酸（NMDA）离子型谷氨酸受体，会引发饱足大鼠的强烈进食行为。为了确定这种进食行为是否是一般行为激活的一部分，我们观察了向AcbSh内注射DNQX对固体食物、液体食物和水的摄入量以及啃咬行为的影响。此外，我们研究了用（±）-α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）激活这些受体的一个亚群是否能够抑制进食的可能性。DNQX显著增加了固体和液体食物的摄入量，但对水的摄入量或啃咬行为没有显著影响。此外，向AcbSh注射AMPA可抑制剥夺诱导的进食以及美味5%蔗糖溶液的摄入量，且不影响缺水大鼠的水摄入量。综上所述，这些数据表明DNQX作用于一个专门参与食物摄入调节的系统。
