Thomas M R, Kirksey A
J Nutr. 1976 Oct;106(10):1415-20. doi: 10.1093/jn/106.10.1415.
The influence of deficient and adequate maternal intakes of pyridoxine on fatty acid profiles in brains of progeny at 5, 10, and 15 days of age was studied. The effects of two different times of initiating rehabilitation of deficient dams on the brain development of progeny at 5, 10, 15, 25, and 50 days of age were also examined. Three groups of weanling, female rats were fed diets deficient in pyridoxine (1.2 mg pyridoxine-HC1/kg diet) and a fourth group received a control diet (30.0 mg pyridoxine-HC1/kg diet) throughout growth, gestation and until 5 and 10 days postpartum. Supplementation with 30.0 mg pyridoxine-HC1/kg was begun in two deficient groups at 5 and 10 days postpartum. Fatty acids C18:2, C20:4, and C22:6 in cerebellum were significantly lower in brains of 15 day-old pups from unsupplemented deficient dams compared to values for pups of control dams. Significant reductions in the omega6 fatty acids (C18:2, C20:4, and C22:4) were evident in cerebellum of 15 day-old progeny of unsupplemented deficient dams. Fatty acids C20:1 and C24:0 were not detectable in cerebellum or cerebrum of the deficient group at 15 days but were evident in other groups. Supplementation of deficient dams with vitamin B-6 at 5 and 10 days postpartum prevented the reduction of omega6 fatty acids found in deficient progeny.
研究了母体缺乏和充足摄入吡哆醇对5日龄、10日龄和15日龄子代大脑脂肪酸谱的影响。还研究了两种不同时间开始对缺乏吡哆醇的母鼠进行恢复处理，对5日龄、10日龄、15日龄、25日龄和50日龄子代大脑发育的影响。三组断奶雌性大鼠在整个生长、妊娠及产后5天和10天期间喂食缺乏吡哆醇的日粮（1.2毫克盐酸吡哆醇/千克日粮），第四组在整个生长、妊娠及产后期间喂食对照日粮（30.0毫克盐酸吡哆醇/千克日粮）。两组缺乏吡哆醇的大鼠在产后5天和10天开始补充30.0毫克盐酸吡哆醇/千克。与对照母鼠的幼崽相比，未补充吡哆醇的缺乏母鼠所生15日龄幼崽大脑小脑的脂肪酸C18:2、C20:4和C22:6显著降低。未补充吡哆醇的缺乏母鼠所生15日龄子代小脑的ω6脂肪酸（C18:2、C20:‘4和C22:4）明显减少。15日龄时，缺乏组的小脑和大脑中未检测到脂肪酸C20:1和C24:0，但在其他组中明显存在。产后5天和10天对缺乏吡哆醇的母鼠补充维生素B-6可防止缺乏子代中ω6脂肪酸的减少。
