Herrera L, Urdaneta-Morales S
Instituto de Zoologia Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Los Chaguaramos, Caracas, Venezuela.
Rev Inst Med Trop Sao Paulo. 1997 Sep-Oct;39(5):279-82. doi: 10.1590/s0036-46651997000500006.
Direct blood examination and xenodiagnosis of 47 synanthropic rodents (Rattus rattus, R. norvegicus, Mus musculus) captured in the valley of Caracas, Venezuela, revealed trypanosomal infections in 12 R. rattus, 10 with T. lewisi and 2 with T. cruzi. Of the latter the course of parasitemia, the pleomorphism of the bloodstream trypomastigotes, tissue in naturally and experimentally infected rats and mice, host mortality, morphology of fecal parasites in Rhodnius prolixus used for xenodiagnosis, and infectivity of the bug feces for NMRI mice, were all characteristic of Trypanosoma (Schizotrypanum) cruzi. One rat, with a patent parasitemia, had numerous nests of amastigotes in cardiac muscle and moderate parasitism of the smooth muscle of the duodenum and of skeletal muscle. Mice inoculated with fecal flagellates from the bugs had moderate tissue tropism in the same organs and also in the colon and pancreas. The possible role of R. rattus in the establishment of foci of Chagas' disease in Caracas is discussed.
对在委内瑞拉加拉加斯山谷捕获的47只家栖啮齿动物（黑家鼠、褐家鼠、小家鼠）进行直接血液检查和异种接种诊断，结果显示，12只黑家鼠感染了锥虫，其中10只感染了刘易斯锥虫，2只感染了克氏锥虫。在后者中，虫血症病程、血液中锥鞭毛体的多形性、自然感染和实验感染大鼠及小鼠的组织情况、宿主死亡率、用于异种接种诊断的长红锥蝽粪便中寄生虫的形态以及锥蝽粪便对NMRI小鼠的感染性，均为克氏锥虫（裂体锥虫属）的特征。一只患有明显虫血症的大鼠，其心肌中有大量无鞭毛体巢，十二指肠平滑肌和骨骼肌有中度寄生虫感染。接种锥蝽粪便鞭毛虫的小鼠在相同器官以及结肠和胰腺中具有中度组织嗜性。文中讨论了黑家鼠在加拉加斯恰加斯病疫源地形成中的可能作用。
