Dahl S G, Jacobsen S
J Pharm Sci. 1976 Sep;65(9):1329-33. doi: 10.1002/jps.2600650917.
A GLC method, based on flame-ionization detection, was developed for the assay of methotrimeprazine and its sulfoxide in plasma. For a 6-ml aliquot, the sensitivity was 2-3 ng/ml for the unchanged drug and 4-5 ng/ml for the sulfoxide. The coefficient of variation, calculated from duplicate analyses of plasma samples, was 8-15% for concentrations between 10 and 100 ng/ml. Patients treated with orally administered methotrimeprazine had higher plasma levels of the sulfoxide than of unmetabolized drug. The method also was applied to the analysis of promazine and chlorpromazine in patient plasma.
建立了一种基于火焰离子化检测的气相色谱法，用于测定血浆中的甲氧异丁嗪及其亚砜。对于6毫升的等分试样，未代谢药物的灵敏度为2 - 3纳克/毫升，亚砜的灵敏度为4 - 5纳克/毫升。根据血浆样品的重复分析计算，浓度在10至100纳克/毫升之间时，变异系数为8 - 15%。口服甲氧异丁嗪治疗的患者血浆中亚砜的水平高于未代谢药物。该方法还应用于患者血浆中丙嗪和氯丙嗪的分析。
