Terryberry J W, Thor G, Peter J B
Specialty Laboratories, Santa Monica, CA 90404, USA.
Neurobiol Aging. 1998 May-Jun;19(3):205-16. doi: 10.1016/s0197-4580(98)00049-9.
The frequency of autoantibodies (AAbs) was surveyed in several neurodegenerative diseases, other neurological diseases, and controls using antigen-specific EIAs for neurofilament heavy subunit, tubulin, glial fibrillary acidic protein, S100 protein, tau, beta-amyloid peptide, myelin basic protein, and heparan sulfate proteoglycan. High frequencies of sera and cerebrospinal fluid tubulin AAbs were found in Alzheimer disease (62% and 69%, respectively), Parkinson disease (27% and 70%), amyotrophic lateral sclerosis (54% and 67%), and in sera from multiple sclerosis (50% and 67%), optic neuritis (85%), Guillain-Barré syndrome (88%), and vascular dementia (52%). High frequencies of neurofilament heavy subunit AAbs were detected in Guillain-Barré syndrome, chronic peripheral neuropathy (88%) and optic neuritis (62%); whereas, some Alzheimer's disease (33%) and vascular dementia (44%) patients had glial fibrillary acidic protein AAbs. Lower frequencies of other AAbs were found in patient groups. AAb results were also compared to functional assessment of blood-brain barrier integrity in Parkinson's disease and Alzheimer's disease. The relevance of these AAbs to pathogenesis and/or course of neurologic diseases merits further study with particular reference to subgrouping and prognosis.
使用针对神经丝重亚基、微管蛋白、胶质纤维酸性蛋白、S100蛋白、tau蛋白、β-淀粉样肽、髓鞘碱性蛋白和硫酸乙酰肝素蛋白聚糖的抗原特异性酶免疫测定法，对几种神经退行性疾病、其他神经系统疾病及对照中的自身抗体（AAbs）频率进行了调查。在阿尔茨海默病（血清和脑脊液中微管蛋白AAbs的频率分别为62%和69%）、帕金森病（27%和70%）、肌萎缩侧索硬化症（54%和67%）以及多发性硬化症血清（50%和67%）、视神经炎（85%）、吉兰-巴雷综合征（88%）和血管性痴呆（52%）中发现了高频率的微管蛋白AAbs。在吉兰-巴雷综合征、慢性周围神经病（88%）和视神经炎（62%）中检测到高频率的神经丝重亚基AAbs；而部分阿尔茨海默病（33%）和血管性痴呆（44%）患者有胶质纤维酸性蛋白AAbs。在各患者组中发现其他AAbs的频率较低。还将AAbs结果与帕金森病和阿尔茨海默病血脑屏障完整性的功能评估进行了比较。这些AAbs与神经疾病发病机制和/或病程的相关性值得进一步研究，特别是在亚组划分和预后方面。
