海蜇毒素的细胞毒性、溶血活性和致断裂活性的体外评估
In vitro evaluation of the cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s).
作者信息
Allavena A, Mariottini G L, Carli A M, Contini S, Martelli A
机构信息
Department of Internal Medicine, Pharmacology and Toxicology Unit, University of Genoa, Italy.
出版信息
Toxicon. 1998 Jun;36(6):933-6. doi: 10.1016/s0041-0101(97)00171-2.
Cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s) contained in the jelly tissue free of nematocysts were investigated in mammalian cells with in vitro procedures. At the concentration of 37.6 microg/ml the tissue protein produced the death of 50% V79 cells; a similar potency was observed in terms of hemolytic activity. The toxin(s) was not clastogenic for human lymphocytes in culture at the concentration of 5 microg/ml.
利用体外实验方法，对无刺丝囊的海蜇组织中所含的海蜇毒素的细胞毒性、溶血活性和致染色体断裂活性进行了研究。在浓度为37.6微克/毫升时，该组织蛋白可导致50%的V79细胞死亡；在溶血活性方面也观察到了类似的效力。在浓度为5微克/毫升时，该毒素对培养中的人淋巴细胞无致染色体断裂作用。
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