Rovaris M, Rocca M A, Capra R, Prandini F, Martinelli V, Comi G, Filippi M
Department of Neurology, IRCCS Ospedale San Raffaele, University of Milan, Italy.
J Neuroimaging. 1998 Jul;8(3):144-7. doi: 10.1111/jon199883144.
In this longitudinal study the authors evaluated the sensitivity of 3-mm and 5-mm magnetic resonance imaging (MRI) of the brain in the detection of lesion load changes over time in multiple sclerosis (MS). The authors also correlated the changes detected with these two techniques with the changes in disability. Eighteen patients with MS underwent two MRI examinations of the brain--one at entrance into the study and one follow-up examination. At both sessions, images with 24 contiguous slices 5 mm thick and another with 40 contiguous axial slices 3 mm thick were consecutively acquired. On the same occasions, the patients' Expanded Disability Status Scale (EDSS) scores were rated. MR images with slices 3 mm thick showed higher lesion loads than those with slices 5 mm thick at both entrance and follow-up examinations (median, 13.4 vs 12.8 ml and 17.5 vs 17.0 ml, respectively; p < 0.0001). The correlation between MRI and EDSS changes was significant for both MRI acquisition schemes (3 mm, r = 0.64; 5 mm, r = 0.59). The data suggest that acquisition of thinner slices does not significantly increase the sensitivity of MRI of the brain in the detection of lesion load changes in MS.
在这项纵向研究中，作者评估了脑部3毫米和5毫米磁共振成像（MRI）在检测多发性硬化症（MS）患者随时间推移的病灶负荷变化方面的敏感性。作者还将这两种技术检测到的变化与残疾程度的变化进行了关联。18例MS患者接受了两次脑部MRI检查，一次在研究开始时，一次在随访时。在两次检查中，分别连续采集了24个5毫米厚的相邻切片图像和40个3毫米厚的相邻轴向切片图像。在相同时间，对患者的扩展残疾状态量表（EDSS）评分。在研究开始和随访检查时，3毫米厚切片的MR图像显示的病灶负荷均高于5毫米厚切片的图像（中位数分别为13.4毫升对12.8毫升和17.5毫升对17.0毫升；p < 0.0001）。两种MRI采集方案（3毫米，r = 0.64；5毫米，r = 0.59）下，MRI与EDSS变化之间的相关性均显著。数据表明，采集更薄的切片并不能显著提高脑部MRI检测MS病灶负荷变化的敏感性。
