Truyen L, Gheuens J, Van de Vyver F L, Parizel P M, Peersman G V, Martin J J
Department of Neurology, University Hospital Antwerp, Belgium.
J Neurol Sci. 1990 May;96(2-3):173-82. doi: 10.1016/0022-510x(90)90130-f.
In a previous study we have shown that the sensitivity of magnetic resonance imaging (MRI) for the detection of multiple sclerosis (MS) lesions was improved significantly, especially in the infratentorial region, by use of an extensive standardized MRI-protocol consisting of sagittal T1, axial protondensity and axial T2, and sagittal protondensity and sagittal moderately T2-weighted images. The goal of the present study was to assess whether the clinical correlation of the visualized lesions had improved accordingly. Using a scoring system based on lesion dimensions, we compared 70 MRI examinations performed in 25 patients with definite MS, with the relevant clinical data as given by the Expanded Disability Status Scale (EDSS) and Functional System scale (FS). We found a significant correlation (r = 0.66, P = 0.0001) between the MRI score and the EDSS. Significant correlations also existed between MRI scores and cerebellar and brainstem FS scores. These correlations were consistently higher than those reported by other authors. We conclude that a standardized MRI examination, including sagittal protondensity and moderately T2-weighted images, should be performed in every MS patient. The improved clinical correlation could be of importance in follow-up studies when assessing the efficacity of therapy.
在之前的一项研究中，我们已经表明，通过使用由矢状位T1、轴位质子密度和轴位T2，以及矢状位质子密度和矢状位中等T2加权图像组成的广泛标准化MRI方案，磁共振成像（MRI）检测多发性硬化（MS）病变的敏感性显著提高，尤其是在后颅窝区域。本研究的目的是评估可视化病变的临床相关性是否相应得到改善。我们使用基于病变大小的评分系统，将25例确诊为MS的患者所进行的70次MRI检查，与扩展残疾状态量表（EDSS）和功能系统量表（FS）给出的相关临床数据进行了比较。我们发现MRI评分与EDSS之间存在显著相关性（r = 0.66，P = 0.0001）。MRI评分与小脑和脑干FS评分之间也存在显著相关性。这些相关性始终高于其他作者报告的相关性。我们得出结论，每位MS患者都应进行包括矢状位质子密度和中等T2加权图像在内的标准化MRI检查。在评估治疗效果的随访研究中，改善的临床相关性可能具有重要意义。
