Modan B, Chetrit A, Alfandary E, Tamir A, Lusky A, Wolf M, Shpilberg O
Department of Clinical Epidemiology, Chaim Sheba Medical Center, and The Stanley Steyer Institute for Cancer Epidemiology and Research, Tel Aviv University School of Medicine, Tel Hashomer, Israel.
Laryngoscope. 1998 Jul;108(7):1095-7. doi: 10.1097/00005537-199807000-00026.
To assess the risk of neoplastic development among persons exposed to scalp irradiation.
Historical cohort study initially; prospective follow-up subsequently.
Two control groups--population and siblings--matched for age, sex, ethnic origin, and year of immigration. Follow-up from time of irradiation (1950s) until the end of 1991. Linkage with nationwide cancer registry.
A 4.5-fold incidence of cancer (P < .01) and a 2.6-fold increase of benign tumors were noted. The mean length of latency period until tumor development was 11 years for malignant tumors and 21.5 years for benign. A clear dose response effect for both cancer and benign tumors was demonstrated.
The study confirms the role of radiation in salivary gland carcinogenesis. It indicates a need for better awareness, a comprehensive examination, and long-term follow-up of patients who have been subjected to head and neck radiation.
评估接受头皮照射者发生肿瘤的风险。
最初为历史性队列研究；随后进行前瞻性随访。
两个对照组——人群和同胞——按年龄、性别、种族和移民年份进行匹配。从照射时间（20世纪50年代）开始随访至1991年底。与全国癌症登记处建立联系。
观察到癌症发病率增加4.5倍（P <.01），良性肿瘤增加2.6倍。恶性肿瘤发展至肿瘤形成的平均潜伏期为11年，良性肿瘤为21.5年。癌症和良性肿瘤均显示出明显的剂量反应效应。
该研究证实了辐射在涎腺癌发生中的作用。这表明对于接受头颈部放疗的患者，需要提高认识、进行全面检查并进行长期随访。
