低剂量辐射后唾液腺肿瘤风险增加。
Increased risk of salivary gland tumors after low-dose irradiation.
作者信息
Modan B, Chetrit A, Alfandary E, Tamir A, Lusky A, Wolf M, Shpilberg O
机构信息
Department of Clinical Epidemiology, Chaim Sheba Medical Center, and The Stanley Steyer Institute for Cancer Epidemiology and Research, Tel Aviv University School of Medicine, Tel Hashomer, Israel.
出版信息
Laryngoscope. 1998 Jul;108(7):1095-7. doi: 10.1097/00005537-199807000-00026.
OBJECTIVE
To assess the risk of neoplastic development among persons exposed to scalp irradiation.
STUDY DESIGN
Historical cohort study initially; prospective follow-up subsequently.
METHOD
Two control groups--population and siblings--matched for age, sex, ethnic origin, and year of immigration. Follow-up from time of irradiation (1950s) until the end of 1991. Linkage with nationwide cancer registry.
RESULTS
A 4.5-fold incidence of cancer (P < .01) and a 2.6-fold increase of benign tumors were noted. The mean length of latency period until tumor development was 11 years for malignant tumors and 21.5 years for benign. A clear dose response effect for both cancer and benign tumors was demonstrated.
CONCLUSIONS
The study confirms the role of radiation in salivary gland carcinogenesis. It indicates a need for better awareness, a comprehensive examination, and long-term follow-up of patients who have been subjected to head and neck radiation.
目的
评估接受头皮照射者发生肿瘤的风险。
研究设计
最初为历史性队列研究；随后进行前瞻性随访。
方法
两个对照组——人群和同胞——按年龄、性别、种族和移民年份进行匹配。从照射时间（20世纪50年代）开始随访至1991年底。与全国癌症登记处建立联系。
结果
观察到癌症发病率增加4.5倍（P <.01），良性肿瘤增加2.6倍。恶性肿瘤发展至肿瘤形成的平均潜伏期为11年，良性肿瘤为21.5年。癌症和良性肿瘤均显示出明显的剂量反应效应。
结论
该研究证实了辐射在涎腺癌发生中的作用。这表明对于接受头颈部放疗的患者，需要提高认识、进行全面检查并进行长期随访。
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