Ron E, Modan B
J Natl Cancer Inst. 1980 Jul;65(1):7-11.
The incidence of all thyroid surgery was studied among 10,842 persons whose thyroid glands had been exposed in childhood to an average dose of 9 rads of X-radiation during treatment for tinea capitis and among 2 matched control groups. A statistically significant increased risk for both benign and malignant neoplasms was found in the exposed group. The excess risk was 8.3 cases/year/rad/million population. There were no differences in other surgical conditions between the irradiated and nonirradiated groups. Persons irradiated under age 6 years had the highest excess risk for developing carcinomas. The incidence of thyroid neoplasms was approximately threefold higher in women than in men among the irradiated persons and among the controls, but the relative risk for the irradiated group of women was greater than the addition of the relative risks of the other groups. Low-dose radiation is instrumental in the development of both benign and malignant thyroid neoplasms.
对10842名在儿童时期因头癣治疗而甲状腺平均接受9拉德X射线辐射的人群以及两个匹配对照组的所有甲状腺手术发生率进行了研究。在暴露组中发现良性和恶性肿瘤的风险均有统计学意义的增加。额外风险为8.3例/年/拉德/百万人口。照射组和未照射组在其他手术情况方面没有差异。6岁以下接受照射的人群患癌的额外风险最高。在接受照射的人群和对照组中，女性甲状腺肿瘤的发生率约为男性的三倍，但照射组女性的相对风险大于其他组相对风险之和。低剂量辐射在良性和恶性甲状腺肿瘤的发生中起作用。
