Pau H
Klin Monbl Augenheilkd. 1976 Apr;168(4):478-80.
Incipient siderosis of the lens is reflected by an extremely fine granular, almost homogenous closely subcapsular brown discoloration between the anterior capsule of the lens and the epithelium. Advanced siderosis of the lens leads to subcapsular "rust spots" of varying size, especially in the region below the pupil; to increasing permeability cataract with protein breakdown and also to brown discoloration of the developing hollow spaces and clefts containing protein. In extensive siderosis of the lens, there was the following histological evidence of iron infiltration colour reactions: Between epithelium and capsule: (fusiformly) changed epithelia, intercellular substance formed by metaplasia of epithelia with connective tissue fibrillae (birefractive capsular cataract), in large, balloon-like epithelial cells freely occurring in the liquefied capsule, by decomposition of these cells in all fluid cavities containing protein (water clefts, etc.). On the other hand, there were no siderous granulations of protein: in normal epithelial cells of the lens, in unchanged fibres of the lens, in Wedl's cells and in Morgagni's or myelin droplets.
晶状体早期铁质沉着表现为晶状体前囊与上皮之间极细微的颗粒状、几乎均匀的紧密的囊下棕色变色。晶状体晚期铁质沉着导致大小不一的囊下“锈斑”，尤其在瞳孔下方区域；导致蛋白分解引起的通透性增加性白内障，还导致含有蛋白质的发育中的中空腔隙和裂隙出现棕色变色。在广泛的晶状体铁质沉着中，有以下铁浸润颜色反应的组织学证据：上皮与囊膜之间：（梭形）改变的上皮，上皮化生形成的含结缔组织纤维的细胞间物质（双折射性囊膜性白内障），在液化囊膜中自由出现的大的气球样上皮细胞，这些细胞在所有含蛋白质的液腔（水隙等）中分解。另一方面，在晶状体正常上皮细胞、未改变的晶状体纤维、韦德尔细胞以及莫尔加尼氏体或髓磷脂滴中没有含铁颗粒。
