Holm L
European Molecular Biology Laboratory-European Bio-informatics Institute, Cambridge, UK.
Curr Opin Struct Biol. 1998 Jun;8(3):372-9. doi: 10.1016/s0959-440x(98)80072-9.
Computational biology exploits the evolutionary connectivity between proteins and protein families to predict structural and functional properties of uncharacterized gene products. In the past year, conceptual and statistical refinements have substantially improved algorithms for the detection of remote homologues. In conjunction with the rapid growth of biological databases, the global organization of proteins into sequence families, functional families and structural families has become both pertinent and feasible.
计算生物学利用蛋白质与蛋白质家族之间的进化联系来预测未表征基因产物的结构和功能特性。在过去的一年里，概念和统计方面的改进极大地提升了检测远源同源物的算法。随着生物数据库的迅速增长，将蛋白质整体组织成序列家族、功能家族和结构家族已变得既相关又可行。
