Wallace M H, Phillips R K
St Mark's Hospital, Harrow, UK.
Br J Surg. 1998 Jun;85(6):742-50. doi: 10.1046/j.1365-2168.1998.00776.x.
Upper gastrointestinal disease has become an important aspect in the management of patients with familial adenomatous polyposis (FAP).
A review of the literature was carried out using Medline. Epidemiology, pathology and treatment options are considered.
Despite the fact that over 90 per cent of patients with FAP develop duodenal adenomas, only 5 per cent go on to develop cancer. In the absence of methods to detect who is at risk of cancer, all patients undergo regular endoscopic surveillance at present. Chemoprevention in the form of drug therapy may be the answer to controlling the disease.
上消化道疾病已成为家族性腺瘤性息肉病（FAP）患者管理中的一个重要方面。
使用Medline对文献进行综述。对流行病学、病理学和治疗选择进行了考量。
尽管超过90%的FAP患者会发生十二指肠腺瘤，但只有5%会发展为癌症。由于缺乏检测癌症风险人群的方法，目前所有患者都要接受定期内镜监测。药物治疗形式的化学预防可能是控制该病的答案。
