抑制蛋白质-蛋白质界面的组装。

Inhibiting the assembly of protein-protein interfaces.

作者信息

Zutshi R, Brickner M, Chmielewski J

机构信息

Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

出版信息

Curr Opin Chem Biol. 1998 Feb;2(1):62-6. doi: 10.1016/s1367-5931(98)80036-7.

DOI:10.1016/s1367-5931(98)80036-7

PMID:9667909

Abstract

Protein-protein association is found throughout mechanisms of cellular growth and differentiation, and viral replication. Inhibiting the assembly of protein complexes, therefore, presents itself as a novel means of inhibition for a wide variety of cellular and viral events. Peptides and small molecules that modify the overall quaternary structure of a selection of receptor-ligand interactions and oligomeric viral enzymes have been developed recently.

摘要

蛋白质-蛋白质相互作用存在于细胞生长、分化以及病毒复制的整个机制中。因此，抑制蛋白质复合物的组装成为了一种针对多种细胞和病毒事件的新型抑制手段。最近已经开发出了能够改变一系列受体-配体相互作用和寡聚体病毒酶整体四级结构的肽和小分子。