Ashraf M, Bloor C M
Am J Cardiol. 1978 Jun;41(7):1185-90. doi: 10.1016/0002-9149(78)90874-3.
Morphologic changes in six glutaraldehyde-fixed porcine heterografts recovered from five patients were studied with light and scanning electron microscopy. Light microscopy showed minimal changes in the valves recovered after 2 months of implantation. Fibrin deposits, red blood cell trapping, disruption of the valve matrix and interstitial edema were noted in heterografts 2 months and 2 years after implantation. In valves examined with scanning electron microscopy, 6 hours after implantation the surface changes varied from normal to patchy disruptions. Two months after inplantation, subendothelial fibers were conspicuous and the geometry of endothelial cells was changed. In valves examined after 6 months in place, many nuclei were burst and fibrin strands were seen over the surfaces. Bacterial infection was observed in two cases. The endothelial cells in the valve implanted for 2 years were completely obscured and some areas were densely covered with fibrillar material where blood cells were trapped in the mesh.
对从5名患者体内回收的6个戊二醛固定的猪异种移植物的形态学变化进行了光镜和扫描电镜研究。光镜显示植入2个月后回收的瓣膜变化极小。在植入后2个月和2年的异种移植物中发现有纤维蛋白沉积、红细胞滞留、瓣膜基质破坏和间质水肿。在扫描电镜检查的瓣膜中，植入后6小时表面变化从正常到片状破坏不等。植入2个月后，内皮下纤维明显，内皮细胞形态改变。在植入6个月后检查的瓣膜中，许多细胞核破裂，表面可见纤维蛋白丝。观察到2例细菌感染。植入2年的瓣膜中的内皮细胞完全消失，一些区域被纤维状物质密集覆盖，血细胞被困在网眼中。
