Piatti G, Gazzola T, Allegra L
Institute of Respiratory Tract Diseases, Milan, Italy.
J Chemother. 1998 Jun;10(3):231-5. doi: 10.1179/joc.1998.10.3.231.
The efficacy of the host defense system is a determining factor for the outcome of antimicrobial events in infected patients. The neutrophil granulocyte plays a key role in the lung's defense against bacterial invasion and in the absence of a sufficient attraction of functionally intact neutrophils in the lung, following bacterial challenge, severe pulmonary infection may result. The involvement of phagocytes in pneumonia is well known: infiltration of lung parenchyma by neutrophils occurs within a short time in response to infection and is followed by an influx of monocytes. We investigated the effects of antimicrobial therapy in pneumonia on polymorphonuclear neutrophil (PMN) phagocytosis.
宿主防御系统的效能是决定感染患者抗菌治疗结果的一个因素。中性粒细胞在肺部抵御细菌入侵中起关键作用，若在细菌攻击后肺部没有足够吸引功能完好的中性粒细胞，可能会导致严重肺部感染。吞噬细胞参与肺炎发病是众所周知的：感染后短时间内中性粒细胞就会浸润肺实质，随后单核细胞涌入。我们研究了肺炎抗菌治疗对多形核中性粒细胞（PMN）吞噬作用的影响。
