Cooper J S, Cohen R, Stevens R E
Department of Radiation Oncology, New York University Medical Center, New York City 10016, USA.
Cancer. 1998 Jul 15;83(2):213-9.
The fifth edition of the American Joint Committee on Cancer staging manual defines new rules for classifying nasopharyngeal carcinoma. The authors tested the value of this new system by applying these rules retrospectively to their previously treated patients and comparing the results with those obtained using the fourth edition of the AJCC staging manual or the Ho staging system.
Information from 107 patients who had biopsy-proven squamous cell carcinoma of the nasopharynx that was treated in a constant fashion with definitive-intent radiation therapy alone at one institution provided the data base for this analysis. The extent of disease of each patient was staged according to the rules of 1) the fourth edition of the AJCC staging manual, 2) the Ho staging system, and 3) the fifth edition of the AJCC staging manual.
The new system appears to be better than the two previous systems. It separated patients into cohorts of more equal size than did either of the other systems. It also correlated with outcome for the study population more appropriately than did the fourth edition of the AJCC staging manual or the Ho staging system.
The fifth edition of the AJCC staging manual appears to be an improvement over the previous AJCC or Ho staging systems for the staging of nasopharyngeal carcinoma.
美国癌症联合委员会（AJCC）分期手册第五版定义了鼻咽癌分类的新规则。作者通过将这些规则回顾性应用于他们之前治疗的患者，并将结果与使用AJCC分期手册第四版或何氏分期系统获得的结果进行比较，来测试这个新系统的价值。
来自107例经活检证实为鼻咽鳞状细胞癌的患者的信息构成了本分析的数据库，这些患者在同一机构仅接受了确定性意图的放射治疗，治疗方式一致。根据以下规则对每位患者的疾病范围进行分期：1）AJCC分期手册第四版；2）何氏分期系统；3）AJCC分期手册第五版。
新系统似乎比前两个系统更好。与其他两个系统相比，它将患者分成了规模更均等的队列。与AJCC分期手册第四版或何氏分期系统相比，它也更恰当地与研究人群的预后相关。
AJCC分期手册第五版在鼻咽癌分期方面似乎比之前的AJCC或何氏分期系统有所改进。
