Nakamoto Y, Guidotti L G, Kuhlen C V, Fowler P, Chisari F V
Division of Experimental Pathology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
J Exp Med. 1998 Jul 20;188(2):341-50. doi: 10.1084/jem.188.2.341.
Hepatocellular carcinoma (HCC) is a common complication of chronic hepatitis B virus (HBV) infection. The pathogenetic mechanisms potentially responsible for HCC during chronic HBV infection are not well defined. This study demonstrates that chronic immune-mediated liver cell injury triggers the development of HCC in the absence of viral transactivation, insertional mutagenesis, and genotoxic chemicals. These results strongly suggest that the immune response to HBV is both necessary and sufficient to cause liver cancer during chronic HBV infection, and that all other procarcinogenic events associated with HCC are probably dependent on this process.
肝细胞癌（HCC）是慢性乙型肝炎病毒（HBV）感染的常见并发症。慢性HBV感染期间可能导致HCC的发病机制尚未明确。本研究表明，在没有病毒反式激活、插入诱变和遗传毒性化学物质的情况下，慢性免疫介导的肝细胞损伤会引发HCC的发生。这些结果强烈表明，对HBV的免疫反应在慢性HBV感染期间既是导致肝癌的必要条件也是充分条件，并且与HCC相关的所有其他致癌事件可能都依赖于这一过程。
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