Li C C, Chiu C H, Wu J L, Huang Y C, Lin T Y
Department of Medicine, Chang Gung Children's Hospital, Kaohsiung, ROC.
Scand J Infect Dis. 1998;30(1):39-42. doi: 10.1080/003655498750002286.
To report the in vitro antibiotic susceptibility of Campylobacter species, we determined the MICs of 6 antibiotics by E-test for 93 human clinical strains and 35 chicken strains. The 6 antimicrobial agents tested were gentamicin, erythromycin, clindamycin, tetracycline, ciprofloxacin, and nalidixic acid. Isolates from humans were significantly more susceptible than chicken strains to erythromycin, clindamycin and ciprofloxacin. Nearly all of the human and chicken strains were susceptible to gentamicin. Among human isolates of C. jejuni, cross-resistance between nalidixic acid and ciprofloxacin was found in 66% of the strains, but none of the nalidixic acid-susceptible strains was resistant to ciprofloxacin. The higher prevalence of ciprofloxacin resistance in this area may be attributable to the large amount use of quinolones in poultry. Because of the high resistance rates of chicken isolates to the commonly used antimicrobial agents, it is necessary to create innovative methods to limit the inappropriate use of antibiotics in poultry in order to prevent the spread of the drug-resistant strains to humans.
为报告弯曲杆菌属的体外抗生素敏感性，我们通过E试验测定了93株人类临床菌株和35株鸡源菌株对6种抗生素的最低抑菌浓度（MIC）。所测试的6种抗菌药物为庆大霉素、红霉素、克林霉素、四环素、环丙沙星和萘啶酸。人类分离株对红霉素、克林霉素和环丙沙星的敏感性显著高于鸡源菌株。几乎所有的人类和鸡源菌株对庆大霉素敏感。在空肠弯曲杆菌的人类分离株中，66%的菌株存在萘啶酸和环丙沙星之间的交叉耐药性，但对萘啶酸敏感的菌株中无一株对环丙沙星耐药。该地区环丙沙星耐药率较高可能归因于家禽中喹诺酮类药物的大量使用。由于鸡源分离株对常用抗菌药物的耐药率较高，有必要创新方法以限制家禽中抗生素的不当使用，从而防止耐药菌株传播给人类。
