Kalliomaa K, Haag-Grönlund M, Victorin K
Department of Computer and Systems Sciences, Stockholm University/The Royal Institute of Technology, Electrum 230, Kista, S-164 40, Sweden.
Regul Toxicol Pharmacol. 1998 Apr;27(2):98-107. doi: 10.1006/rtph.1997.1184.
The benchmark dose concept is an alternative way to calculate acceptable daily intakes or other low-risk limits of exposure for nongenotoxic compounds. An effective dose that corresponds to a specific change of effect/response, e.g., 10%, over background, on a given model is calculated and a benchmark dose which is the lower confidence bound for the effective dose can be estimated. One problem with this method is that it has not been possible to model "S"-shaped curves for continuous data with the existing commercial computer programs. We present a new mathematical model for continuous data, which can form S-shaped curves. For a number of data sets on the toxicity of trichloroethene, the introduction of this new function significantly increased the possibilities to model continuous data. A new computer package has also been developed to improve and simplify the calculations of benchmark doses.
基准剂量概念是计算非遗传毒性化合物可接受的每日摄入量或其他低风险暴露限值的另一种方法。在给定模型上，计算出与效应/反应的特定变化（例如，相对于背景变化10%）相对应的有效剂量，并可以估计作为有效剂量下限置信区间的基准剂量。该方法存在的一个问题是，使用现有的商业计算机程序无法对连续数据的“S”形曲线进行建模。我们提出了一种针对连续数据的新数学模型，该模型可以形成“S”形曲线。对于一些关于三氯乙烯毒性的数据集，引入这个新函数显著增加了对连续数据进行建模的可能性。还开发了一个新的计算机软件包，以改进和简化基准剂量的计算。
