野生型和疫苗麻疹病毒长链非编码M-F基因组区域的比较研究

Comparative investigation of the long non-coding M-F genome region of wild-type and vaccine measles viruses.

作者信息

Heider A, Santibanez S, Tischer A, Gerike E, Tikhonova N, Ignatyev G, Mrazova M, Enders G, Schreier E

机构信息

Research Institute of Viral Preparations, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Arch Virol. 1997;142(12):2521-8. doi: 10.1007/s007050050259.

DOI:10.1007/s007050050259

PMID:9672611

Abstract

The sequence of the 300 nucleotides region of the measles virus genome was determined that includes a part of the 3'-untranslated region of the matrix (M) gene, the intergenic region and a part of the 5'-untranslated region of the fusion (F) gene [M-F region] for vaccine strain Leningrad-16 and 14 wild-type isolates. The data obtained demonstrate the variability of this long non-coding M-F region. No mutations in this region of the genome were found which seem to be specific for vaccine strains of measles virus (MV).

摘要

测定了麻疹病毒基因组300个核苷酸区域的序列，其中包括基质（M）基因3'非翻译区的一部分、基因间隔区以及融合（F）基因5'非翻译区的一部分[M-F区域]，涉及疫苗株列宁格勒-16和14株野生型分离株。所获得的数据表明了这个长的非编码M-F区域的变异性。在该基因组区域未发现似乎是麻疹病毒（MV）疫苗株特有的突变。