Niemann A M, Werner J A
Dept. of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.
Otolaryngol Pol. 1998;52(2):141-5.
Amyloidosis is a rare disease in otorhinolaryngology. It presents a wide range of clinical manifestations and its deposits can be found in various organs. In the paper, a case of a 73-year-old female patient with macroglossia, as a symptom of nodular amyloidosis is reported. The predominant features were dysphagia and speech impairment caused by the tongue protruding beyond the teeth. The histologic appearance consisted of a nodular pattern of amyloid deposition. The amyloid was of an AL (lambda-light chain) type as shown immunohistochemically. The presented case shows the importance of investigating the patient for co-existing disease.
淀粉样变性是耳鼻咽喉科的一种罕见疾病。它有广泛的临床表现，其沉积物可在多个器官中发现。本文报道了一例73岁女性患者，以巨舌症为结节性淀粉样变性的症状。主要特征是吞咽困难和因舌头伸出牙齿外导致的言语障碍。组织学表现为淀粉样蛋白沉积的结节状模式。免疫组织化学显示淀粉样蛋白为AL（λ轻链）型。该病例表明对患者进行并存疾病检查的重要性。
