CD8缺陷小鼠对寄生虫硕大利什曼原虫具有有效且持久的免疫力。
Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.
作者信息
Huber M, Timms E, Mak T W, Röllinghoff M, Lohoff M
机构信息
Institut für Klinische Mikrobiologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
出版信息
Infect Immun. 1998 Aug;66(8):3968-70. doi: 10.1128/IAI.66.8.3968-3970.1998.
Abstract
The results of earlier investigations that tested whether CD8(+) T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue. After primary infection with L. major, CD8-deficient mice controlled the infection for over 1 year and mounted strong T helper 1 cell responses. Thus, CD8(+) T cells are not required for the long-term control of a primary infection with L. major.
摘要
早期关于检测CD8(+) T细胞在抵抗硕大利什曼原虫感染中是否必需的研究结果并不一致。我们使用CD8基因缺陷小鼠直接解决这个问题。在用硕大利什曼原虫进行初次感染后，CD8基因缺陷小鼠控制感染长达1年以上，并产生了强烈的辅助性T细胞1型反应。因此，在对硕大利什曼原虫的初次感染进行长期控制中，CD8(+) T细胞并非必需。
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