幽门螺杆菌空泡毒素与靶细胞的结合。
Binding of the Helicobacter pylori vacuolating cytotoxin to target cells.
作者信息
Massari P, Manetti R, Burroni D, Nuti S, Norais N, Rappuoli R, Telford J L
机构信息
IRIS, Chiron Vaccines, 53100 Siena, Italy.
出版信息
Infect Immun. 1998 Aug;66(8):3981-4. doi: 10.1128/IAI.66.8.3981-3984.1998.
Abstract
The vacuolating cytotoxin of Helicobacter pylori, VacA, enters the cytoplasm of target cells and causes vacuolar degeneration by interfering with late stages of endocytosis. By using indirect immunofluorescence and flow cytometry, we have demonstrated that VacA binds to specific high-affinity cell surface receptors and that this interaction is necessary for cell intoxication.
摘要
幽门螺杆菌的空泡毒素VacA进入靶细胞的细胞质，并通过干扰内吞作用的后期阶段导致空泡变性。通过间接免疫荧光和流式细胞术，我们已经证明VacA与特定的高亲和力细胞表面受体结合，并且这种相互作用对于细胞中毒是必需的。
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