Nanda G S, Sun F X, Hofmann G A, Hoffman R M, Dev S B
Genetronics, Inc., San Diego, CA 92121, USA.
Anticancer Res. 1998 May-Jun;18(3A):1361-6.
A new method of cancer treatment called electroporation therapy (EPT) which uses pulsed electric fields in combination with a chemotherapeutic agent is being developed to treat human pancreatic tumors. Such a combination has been found to increase the cytotoxic effect of the drug to tumor cells.
Human pancreatic tumors (Pan-4-JCK) were implanted subcutaneously onto nude mice. The animals were treated with EPT using bleomycin, mitomycin C or carboplatin as a single agent, and their effect on tumor growth was monitored over a period of 89 days.
The tumors treated with either the drug or pulse alone showed increased tumor growth. However, tumors treated with EPT using any one of the three drugs showed significant to complete regression of tumors. Among the three drugs used, the order of efficacy was: bleomycin >> mitomycin C > carboplatin.
These results are sufficient to warrant limited clinical trials of EPT for pancreatic cancers.
一种名为电穿孔疗法（EPT）的癌症治疗新方法正在研发中，该方法将脉冲电场与化疗药物联合使用来治疗人类胰腺肿瘤。已发现这种联合使用可增强药物对肿瘤细胞的细胞毒性作用。
将人胰腺肿瘤（Pan - 4 - JCK）皮下植入裸鼠体内。使用博来霉素、丝裂霉素C或卡铂作为单一药物对动物进行电穿孔疗法治疗，并在89天的时间内监测其对肿瘤生长的影响。
单独使用药物或脉冲治疗的肿瘤显示出肿瘤生长增加。然而，使用这三种药物中的任何一种进行电穿孔疗法治疗的肿瘤显示出肿瘤显著至完全消退。在所使用的三种药物中，疗效顺序为：博来霉素>>丝裂霉素C>卡铂。
这些结果足以保证对胰腺癌进行电穿孔疗法的有限临床试验。
