患有利什曼病的犬类中循环免疫复合物IgM和IgA的水平。

Levels of IgM and IgA circulating immune complexes in dogs with leishmaniasis.

作者信息

Margarito J M, Lucena R, López R, Molleda J M, Martín E, Ginel P J

机构信息

Department of Veterinary Clinical Pathology, Faculty of Veterinary of Córdoba, Spain.

出版信息

Zentralbl Veterinarmed B. 1998 Jun;45(5):263-7. doi: 10.1111/j.1439-0450.1998.tb00793.x.

DOI:10.1111/j.1439-0450.1998.tb00793.x

PMID:9673577

Abstract

The concentrations of IgM and IgA circulating immune complexes (CIC) were determined in 82 dogs with naturally acquired leishmania infection and in a control group of 25 healthy dogs. The mean serum IgM and IgA CIC concentration in infected dogs were significantly (IgM; P < 0.004; IgA; P < 0.000) higher than in the control group. An increase in IgM and IgA CIC concentration was found in 47.6 and 95.1%, respectively, of the leishmania-infected dogs. The serum IgM and IgA CIC concentrations in infected dogs showing hypercreatininaemia were not statistically higher than those of sick dogs with normal creatininaemia. When hypercreatininaemia (> or = 1.30 mg/dl) was used as an indicator for CIC disease, the positive predictive value obtained with 0.368 for IgM CIC and 0.894 for IgA CIC, indicating that renal function impairment was associated with the high serum IgM and IgA CIC concentrations in 36.8 and 89.4%, respectively, of the infected dogs.

摘要

对82只自然感染利什曼原虫的犬以及25只健康犬组成的对照组测定了IgM和IgA循环免疫复合物（CIC）的浓度。感染犬血清IgM和IgA CIC的平均浓度显著高于对照组（IgM；P < 0.004；IgA；P < 0.000）。分别在47.6%和95.1%的利什曼原虫感染犬中发现IgM和IgA CIC浓度升高。出现高肌酐血症的感染犬血清IgM和IgA CIC浓度在统计学上并不高于肌酐血症正常的患病犬。当将高肌酐血症（≥1.30 mg/dl）用作CIC疾病的指标时，IgM CIC的阳性预测值为0.368，IgA CIC的阳性预测值为0.894，这表明在分别36.8%和89.4%的感染犬中，肾功能损害与血清IgM和IgA CIC高浓度相关。