Baba T, Yamashita N, Kodama H, Mukamoto M, Asada M, Nakamoto K, Nose Y, McGruder E D
Department of Veterinary Immunology, College of Agriculture, Osaka Prefecture University, Japan.
Zentralbl Veterinarmed B. 1998 Jun;45(5):279-86. doi: 10.1111/j.1439-0450.1998.tb00795.x.
While many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance the immune function. Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on the humoral immune functions in chickens. Three days after oral tylosin tartrate administration, 4- or 8-week-old chickens were immunized intravenously with carbolic acid-killed Brucella abortus bacterin or sheep red blood cells. Seven days (plasma antibodies titre) or 4 days (antibody forming cells) post-immunization, there was a significant increase in antibody production as well as in the numbers of antibody-producing cells in tylosin tartrate-administered chickens compared with the untreated controls. However, 3 days after tylosin tartrate administration, there was no difference in the distribution of T-lymphocyte subpopulations (CD4 or CD8 positive cells) or B lymphocytes (surface immunoglobulin positive cells) in either the peripheral blood or spleens or untreated control chickens.
虽然已有报道称许多抗菌剂会导致动物免疫抑制，但大环内酯类抗生素可增强免疫功能。酒石酸泰乐菌素是一种被批准用于控制家禽支原体病的大环内酯类抗生素。本研究的目的是确定泰乐菌素对鸡体液免疫功能的影响。口服酒石酸泰乐菌素三天后，对4周龄或8周龄的鸡静脉注射石炭酸灭活的流产布鲁氏菌菌苗或绵羊红细胞进行免疫。免疫后7天（血浆抗体滴度）或4天（抗体形成细胞），与未处理的对照组相比，给予酒石酸泰乐菌素的鸡的抗体产生以及抗体产生细胞数量显著增加。然而，在给予酒石酸泰乐菌素三天后，外周血、脾脏或未处理的对照鸡的T淋巴细胞亚群（CD4或CD8阳性细胞）或B淋巴细胞（表面免疫球蛋白阳性细胞）的分布没有差异。
