Baba T, Yamashita N, Kodama H, Mukamoto M, Asada M, Nakamoto K, Nose Y, McGruder E D
Department of Veterinary Immunology, College of Agriculture, Osaka Prefecture University, Sakai, Japan.
Poult Sci. 1998 Sep;77(9):1306-11. doi: 10.1093/ps/77.9.1306.
Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on cellular immune functions in chickens. There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased antitumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied.
虽然据报道许多抗菌剂会导致动物免疫抑制，但大环内酯类抗生素可增强免疫功能。泰乐菌素是一种被批准用于控制家禽支原体病的大环内酯类抗生素。本研究的目的是确定泰乐菌素对鸡细胞免疫功能的影响。经泰乐菌素处理的鸡和未处理（对照）的鸡之间，贴壁脾细胞趋化性没有显著差异。泰乐菌素使脾细胞增殖和脾细胞条件培养基（CM）增殖活性高于对照水平。制备CM之前去除贴壁脾细胞会导致CM增殖活性降低。泰乐菌素还增强了脾细胞的抗肿瘤活性。这些数据首次表明，大环内酯类抗生素酒石酸泰乐菌素对所研究的鸡免疫参数具有调节作用。
