Yagi Y, McLellan T S, Frez W A, Clewell D B
Antimicrob Agents Chemother. 1978 May;13(5):884-7. doi: 10.1128/AAC.13.5.884.
A plasmid determining resistance to erythromycin (inducible), lincomycin, and vernamycin B(alpha) was isolated from a strain of Streptococcus sanguis isolated from dental plaque of a patient who had been on erythromycin therapy for an extended period of time. The plasmid, designated pAM77, had a molecular weight of 4.5 x 10(6) and was present to the extent of one to two copies per bacterial chromosome. The plasmid could transform S. sanguis strain Challis.
从一名长期接受红霉素治疗患者的牙菌斑分离出的血链球菌菌株中,分离出一种决定对红霉素(可诱导型)、林可霉素和维那霉素B(α)耐药的质粒。该质粒命名为pAM77,分子量为4.5×10⁶,每个细菌染色体中有一到两个拷贝。该质粒可转化血链球菌Challis菌株。