Clewell Don B
Biologic and Materials Sciences; School of Dentistry and Microbiology and Immunology; Medical School; The University of Michigan; Ann Arbor, MI USA.
Mob Genet Elements. 2011 May;1(1):38-54. doi: 10.4161/mge.1.1.15409.
This review covers highlights of the author's experience becoming and working as a plasmid biologist. The account chronicles a progression from studies of ColE1 DNA in Escherichia coli to Gram-positive bacteria with an emphasis on conjugation in enterococci. It deals with gene amplification, conjugative transposons and sex pheromones in the context of bacterial antibiotic resistance.
本综述涵盖了作者成为质粒生物学家并开展相关工作的经历要点。该记述按时间顺序呈现了从对大肠杆菌中ColE1 DNA的研究到革兰氏阳性菌研究的进展,重点是肠球菌中的接合作用。它在细菌抗生素耐药性的背景下探讨了基因扩增、接合转座子和性信息素。