Tomadoni A E, Wainstein R C
Servicio de Oncología, Hospital Nacional Prof. Alejandro Posadas, Haedo.
Medicina (B Aires). 1998;58(1):41-4.
Twenty three HIV+ patients with cancer (2% of the infected population: 1100 patients) were treated at our Hospital between January 1987 and July 1997. Twelve patients (52%) had Kaposi's sarcoma (KS), five (22%) presented non Hodgkin lymphoma--B cell type (NHL), the remaining patients presented other non AIDS defining neoplasias. The patients with NHL presented, at the time of diagnosis, several infrequent localizations, poor tolerance to chemotherapy with a mean survival of 3 months. The patients with Kaposi sarcoma had neither positive response to recombinant Interferon alfa 2 nor to the etoposide regimens. A relatively high percentage (13%) of Hodgkin-disease (HL) was observed. Unlike previously consulted data, there was no apparent increased incidence of NHL. HIV+ patients with cancer who underwent conventional radiotherapy presented major toxicity and adverse effects not currently observed in non HIV+ patients.
1987年1月至1997年7月期间，我院共治疗了23例合并癌症的HIV阳性患者（占感染人群的2%：共1100例患者）。其中12例（52%）患有卡波西肉瘤（KS），5例（22%）为非霍奇金淋巴瘤——B细胞型（NHL），其余患者患有其他非艾滋病相关定义的肿瘤。NHL患者在诊断时出现了几种罕见的定位情况，对化疗耐受性差，平均生存期为3个月。卡波西肉瘤患者对重组干扰素α2和依托泊苷方案均无阳性反应。观察到相对较高比例（13%）的霍奇金病（HL）。与之前查阅的数据不同，NHL的发病率没有明显增加。接受传统放疗的合并癌症的HIV阳性患者出现了非HIV阳性患者目前未观察到的严重毒性和不良反应。
