多种抗诱变机制影响碱基类似物6-N-羟基氨基嘌呤在细菌和酵母中的诱变活性和特异性。
Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast.
作者信息
Kozmin S G, Schaaper R M, Shcherbakova P V, Kulikov V N, Noskov V N, Guetsova M L, Alenin V V, Rogozin I B, Makarova K S, Pavlov Y I
机构信息
Department of Genetics, Sankt-Petersburg University, Sankt-Petersburg, 199034, Russian Federation.
出版信息
Mutat Res. 1998 Jun 18;402(1-2):41-50. doi: 10.1016/s0027-5107(97)00280-7.
Base analog 6-N-hydroxylaminopurine is a potent mutagen in variety of prokaryotic and eukaryotic organisms. In the review, we discuss recent results of the studies of HAP mutagenic activity, genetic control and specificity in bacteria and yeast with the emphasis to the mechanisms protecting living cells from mutagenic and toxic effects of this base analog.
碱基类似物6-N-羟基氨基嘌呤在多种原核生物和真核生物中是一种强效诱变剂。在这篇综述中，我们讨论了关于HAP在细菌和酵母中的诱变活性、遗传控制和特异性研究的最新结果，重点是保护活细胞免受这种碱基类似物诱变和毒性作用的机制。
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