Papierkowski A, Pasternak K
Observation Clinic, Medical Academy of Lublin, Poland.
Magnes Res. 1998 Jun;11(2):85-9.
The effect of a single dose of morphine (50 mg/kg) and ethanol (2 g/kg) on total magnesium content in blood serum, brain, heart, lung, kidney, liver, femoral muscle and spleen in mice was studied. Significant decrease of magnesium serum concentration was observed after morphine and ethanol administration but not after both drugs given simultaneously. Morphine caused the evident decrease of magnesium content in brain, lung, kidney and muscle, while it was elevated in heart and spleen and unchanged in liver. Ethanol produced significant decrease of magnesium content in heart, lung and kidney and it's increase in liver and spleen. Concomitant administration of both drugs was connected with the diminished amount of magnesium in heart, lung, kidney and muscle and led to the rising of magnesium content in spleen. It is concluded that even a single dose of investigated drugs is sufficient to produce promptly some risk of alterations in magnesium homeostasis.
研究了单剂量吗啡（50毫克/千克）和乙醇（2克/千克）对小鼠血清、脑、心脏、肺、肾、肝、股肌和脾脏中总镁含量的影响。给予吗啡和乙醇后观察到血清镁浓度显著降低，但同时给予两种药物后未出现这种情况。吗啡导致脑、肺、肾和肌肉中的镁含量明显降低，而心脏和脾脏中的镁含量升高，肝脏中的镁含量无变化。乙醇使心脏、肺和肾中的镁含量显著降低，肝脏和脾脏中的镁含量增加。两种药物同时给药与心脏、肺、肾和肌肉中镁含量减少有关，并导致脾脏中镁含量升高。得出的结论是，即使是单剂量的受试药物也足以迅速产生镁稳态改变的某些风险。
