Tesh V L
Dept of Medical Microbiology and Immunology, Texas A&M University Health Science Center, College Station 77843-1114, USA.
Trends Microbiol. 1998 Jun;6(6):228-33. doi: 10.1016/s0966-842x(98)01282-7.
Many bacterial exotoxins, originally defined by cytopathic effects, may also possess additional biological activities. The capacity of exotoxins to elicit the synthesis and secretion of pro- or anti-inflammatory cytokines may be as important as their direct toxic effects in pathogenesis. One example of such 'molecular crosstalk' occurs between Shiga toxins and the cytokines made in response to these toxins during the development of disease.
许多最初根据细胞病变效应定义的细菌外毒素也可能具有其他生物学活性。外毒素引发促炎或抗炎细胞因子合成与分泌的能力在发病机制中可能与其直接毒性作用同样重要。这种“分子串扰”的一个例子发生在志贺毒素与疾病发展过程中针对这些毒素产生的细胞因子之间。
