Nicolas G, Bouhour J B, Godin J F, Rozo L, Chareyre M
Arch Mal Coeur Vaiss. 1978 Apr;71(4):471-6.
When considered strictly from the viewpoint of actions on the myocardium, the number of drugs falling into this category is limited, but the resulting conditions may be serious. The prototype for cardiac toxicity is the group of antimitotic drugs (adriamycin or daunomycin). If these drugs are used; frequent and careful follow-up is necessary, the dosage at which the drug becomes cumulative must be known; and patients with a pre-existing cardiac condition must be exluded from treatment. Above all, it is essential not to wait until asystole occurs, but to try to prevent such occurrences by monitoring the patient electrocardiographically. A part from these drugs, recent articles in the literature suggest that similar care should be taken when prescribing emetine and lithium salts. There is insufficient information about other drugs which may have a certain degree of cardiotoxicity. For this reason, it is most important to gather information on accidents and reaction during treatment.
严格从对心肌的作用角度考虑，这类药物的数量有限，但由此产生的情况可能很严重。心脏毒性的典型代表是抗有丝分裂药物（阿霉素或柔红霉素）。如果使用这些药物，必须进行频繁且仔细的随访，必须知道药物开始累积的剂量，并且必须将已有心脏疾病的患者排除在治疗之外。最重要的是，绝不能等到心脏停搏发生，而应通过心电图监测患者来试图预防此类情况的发生。除了这些药物外，文献中的近期文章表明，在开具吐根碱和锂盐处方时也应采取类似的谨慎措施。关于其他可能具有一定程度心脏毒性的药物，信息不足。因此，收集治疗期间的不良事件和反应信息至关重要。
