Takeuchi E, Shimizu E, Sano N, Yamaguchi T, Yanagawa H, Sone S
Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan.
Anticancer Res. 1998 May-Jun;18(3B):2015 -20.
Pleomorphic adenoma of the lung is a rare neoplasm. Here we describe the first report on oncogenes and tumor suppressor genes in metastasizing pleomorphic adenoma of the lung. A 48-year-old Japanese woman presented with metastasizing pleomorphic adenoma in which both the primary lung tumor and metastatic lesions were composed of benign pleomorphic structures. The mechanism of the metastatic potential was examined by analyzing known oncogenes and tumor suppressor genes by DNA blot analysis and immunohistochemistry. No rearrangements amplifications or overexpressions of oncogenes, bcl-2, c-erbB-2, c-myc, L-myc, N-myc, Ha-ras and Ki-ras were found. In addition, immunohistochemical studies showed no aberrance in expressions of the tumor suppressor gene products, RB, p16 and p53 in the tumor. Some unknown mechanism(s) seems to be responsible for the aggressiveness of this metastasizing pleomorphic adenoma. This mechanism must be elucidated by studies on further case of this rare tumor.
肺多形性腺瘤是一种罕见的肿瘤。在此，我们描述了首例关于肺转移性多形性腺瘤中癌基因和肿瘤抑制基因的报告。一名48岁的日本女性患有肺转移性多形性腺瘤，其原发性肺肿瘤和转移灶均由良性多形性结构组成。通过DNA印迹分析和免疫组织化学分析已知的癌基因和肿瘤抑制基因，研究转移潜能的机制。未发现癌基因bcl-2、c-erbB-2、c-myc、L-myc、N-myc、Ha-ras和Ki-ras的重排、扩增或过表达。此外，免疫组织化学研究显示肿瘤中肿瘤抑制基因产物RB、p16和p53的表达无异常。某些未知机制似乎是这种转移性多形性腺瘤具有侵袭性的原因。必须通过对这种罕见肿瘤的更多病例研究来阐明这一机制。
