Hata A, Shi Y, Massagué J
Cell Biology Program, Howard Hughes Medical Institute, New York, NY, USA.
Mol Med Today. 1998 Jun;4(6):257-62. doi: 10.1016/s1357-4310(98)01247-7.
Transforming growth factor-beta (TGF-beta) and related cytokines control the development and homeostasis of many tissues by regulating the expression of genes that determine cell phenotype. Recent progress has elucidated the way in which members of the TGF-beta family initiate their signal through transmembrane receptors and transmit it to target genes via the Smad family of signal-transducing proteins. This review describes TGF-beta signaling pathways as currently understood and mutations of the genes that encode Smads that disrupt the function of these proteins and cause various forms of cancer.
转化生长因子-β（TGF-β）及相关细胞因子通过调节决定细胞表型的基因表达来控制许多组织的发育和内环境稳定。最近的研究进展阐明了TGF-β家族成员通过跨膜受体启动信号并经由信号转导蛋白Smad家族将其传递至靶基因的方式。本综述描述了目前所了解的TGF-β信号通路以及编码Smads的基因发生突变后破坏这些蛋白质功能并导致各种癌症的情况。
