Luttik R
Centre for Substances and Risk Assessment, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Ecotoxicol Environ Saf. 1998 Jul;40(3):201-5. doi: 10.1006/eesa.1998.1684.
The purposes of this article are to present a method that takes into account avoidance behavior in the evaluation of LC50 studies with birds and to provide a concept for the use of food avoidance behavior in the environmental hazard/risk assessment of pesticides used in agriculture for birds. An analysis is made of the standard LC50 test and of three types of food avoidance tests. It is concluded that the standard dietary LC50 test provides most of the information necessary to understand the repellent properties of a pesticide. It is recommended that food consumption be measured daily and that information be provided about the learning abilities of the species tested (when does food avoidance appear). A method is proposed to calculate the no-repellent concentration (NoRC). The NoRC is the concentration in the treated food at which the birds in the test will eat the same amount of treated food as the control group eats untreated food. These small alterations of the standard LC50 test make other repellency tests with birds superfluous. Those repellency tests can be used to provide information about the edibility of the granules and seeds (coated or pillorized, but not treated with a substance), which results in less suffering for test animals.
本文的目的是提出一种在鸟类半数致死浓度(LC50)研究评估中考虑回避行为的方法,并为在农业用农药对鸟类的环境危害/风险评估中利用食物回避行为提供一个概念。对标准LC50试验和三种食物回避试验进行了分析。得出的结论是,标准饮食LC50试验提供了理解农药驱避特性所需的大部分信息。建议每天测量食物消耗量,并提供有关受试物种学习能力的信息(食物回避何时出现)。提出了一种计算无驱避浓度(NoRC)的方法。NoRC是受试食物中的浓度,在该浓度下,试验中的鸟类食用的受试食物量与对照组食用的未处理食物量相同。对标准LC50试验的这些小改动使其他鸟类驱避试验变得多余。那些驱避试验可用于提供有关颗粒和种子(包衣或制成丸剂,但未用物质处理)可食性的信息,这会减少试验动物的痛苦。