Gromiha M M, Selvaraj S
Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
Protein Eng. 1998 Apr;11(4):249-51. doi: 10.1093/protein/11.4.249.
Information about the secondary structure of a protein can be helpful in understanding its native folded state. In previous work, it was shown that the medium-range interactions predominate in all-alpha class and the long-range interactions predominate in all-beta class proteins. Based on this, in this work the performance of several structure prediction methods in different structural classes of globular proteins was analyzed. It was found that all the methods predict the secondary structures of all-alpha proteins more accurately than other classes.
有关蛋白质二级结构的信息有助于理解其天然折叠状态。在先前的工作中，研究表明中程相互作用在全α类蛋白质中占主导地位，而远程相互作用在全β类蛋白质中占主导地位。基于此，在本研究中分析了几种结构预测方法在球状蛋白质不同结构类别的性能。结果发现，所有方法预测全α蛋白质二级结构的准确性均高于其他类别。
