Antoniades J, Croll M N, Walner R J, Brady L W
Radiol Clin (Basel). 1976;45(5):372-9.
Spleen and liver represent target organs for involvement in patients with Hodgkin's disease and with non-Hodgkin's lymphomas. Although histological examination remains the most reliable method in diagnosing the presence of disease in these organs, particularly during the early phases, exploratory laparotomy and liver biopsy cannot be repeated, for practical purposes, on a regular basis. As the incidence of splenic and hepatic involvement continues to rise in the years following the initial diagnosis, we have found that liver and spleen scans performed in a serial manner are helpful in establishing the diagnosis during the follow-up period. By comparing the later studies to the earlier ones, interval changes as related to the size, contour, homogeneity and to the presence or absence of filling defects, become apparent. These changes, should they occur, are related, in our experience to the underlying lymphoma. Conversely, through serial scanning, improvement under treatment of a previously involved organ, is well demonstrated by this noninvasive technique. The limitations imposed by the resolving power of the imaging system must be taken into consideration when interpreting the results.
脾脏和肝脏是霍奇金病和非霍奇金淋巴瘤患者可能受累的靶器官。尽管组织学检查仍然是诊断这些器官疾病存在的最可靠方法，尤其是在疾病早期，但出于实际考虑，探查性剖腹术和肝脏活检不能定期重复进行。在初次诊断后的几年里，脾脏和肝脏受累的发生率持续上升，我们发现连续进行的肝脏和脾脏扫描有助于在随访期间确立诊断。通过将后续研究与早期研究进行比较，与大小、轮廓、均匀性以及充盈缺损的有无相关的间隔变化变得明显。根据我们的经验，这些变化如果发生，与潜在的淋巴瘤有关。相反，通过连续扫描，这种非侵入性技术能很好地显示先前受累器官在治疗下的改善情况。在解释结果时，必须考虑成像系统分辨率所带来的局限性。
