Broliden K, Tolfvenstam T, Ohlsson S, Henter J I
Department of Clinical Virology, Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
Med Pediatr Oncol. 1998 Aug;31(2):66-72. doi: 10.1002/(sici)1096-911x(199808)31:2<66::aid-mpo4>3.0.co;2-x.
The frequency and clinical importance of parvovirus B19 infection were studied in children investigated or treated for various malignancies and cytopenias.
B19 infection was thus demonstrated in six out of 53 unselected children with malignancies by bone marrow examination, using the B19, DNA-specific, polymerase chain reaction (PCR). Examinations using the PCR in serum samples were equally or less sensitive than in bone marrow samples. One of the children had a persistent B19 infection during maintenance therapy for acute lymphoblastic leukemia. She developed a prolonged and severe cytopenia, and the clinical signs included facial rash, chills, high undulating fever, and pharyngitis. She also seroconverted and became B19 IgM-antibody positive during the study period.
Parvovirus B19 infection was detected in 10% of the children and was either asymptomatic or was associated with severe and prolonged cytopenia. Bone marrow examinations are recommended for the detection of B19 DNA in immunosuppressed children.
对因各种恶性肿瘤和血细胞减少症接受检查或治疗的儿童，研究了细小病毒B19感染的频率及其临床重要性。
通过骨髓检查，采用B19 DNA特异性聚合酶链反应（PCR），在53例未经挑选的患有恶性肿瘤的儿童中，有6例证实存在B19感染。血清样本的PCR检测敏感性与骨髓样本相同或更低。其中一名儿童在急性淋巴细胞白血病维持治疗期间发生持续性B19感染。她出现了持续且严重的血细胞减少，临床症状包括面部皮疹、寒战、高热波动以及咽炎。在研究期间，她还发生了血清转化，B19 IgM抗体呈阳性。
在10%的儿童中检测到细小病毒B19感染，感染要么无症状，要么与严重且持续的血细胞减少有关。对于免疫抑制儿童，建议进行骨髓检查以检测B19 DNA。
