Krüger C, Rauh M, Dörr H G
Division of Endocrinology, Hospital for Children and Adolescents, University of Erlangen-Nürnberg, Erlangen, Germany.
Clin Chim Acta. 1998 Jun 8;274(1):15-27. doi: 10.1016/s0009-8981(98)00044-8.
We establish normative data for immunoreactive renin concentration in serum of healthy children. In a retrospective study, surplus sera of 281 healthy children, aged 0-18 years, were collected from the laboratory. The determinations were performed with a commercially available two-site immunoradiometric assay. Functional sensitivity was 4.0 mU/l, inter-assay and intra-assay variance were 7.0-18.3% and 3.8-7.5%, respectively. In umbilical cord and during the first 4 days of life, renin concentrations (geometric mean) were significantly higher (P < 0.05) than in older infants and children [umbilical cord: 155.2 mU/l; newborn infants (2-4 days of life): 90.9; newborn infants (5-7 days of life): 32.5; 2 weeks-3 months: 40.8; 4 months-1 year: 54.5; 1-3 years: 46.3; 3-5 years: 48.5; 5-7 years: 51.6; 7-11 years: 38.5; 11-15 years: 37.7; 15-18 years: 31.9]. Newborn infants delivered by Caesarian section had significantly lower renin concentrations in umbilical cord than those delivered vaginally (P < 0.02). Considering the methodological advantages and disadvantages of plasma renin activity and renin concentration assays, renin measurement was at least as valuable and accurate as plasma renin activity determination.
我们建立了健康儿童血清中免疫反应性肾素浓度的标准数据。在一项回顾性研究中，从实验室收集了281名0至18岁健康儿童的剩余血清。采用市售的双位点免疫放射分析进行测定。功能灵敏度为4.0 mU/l，批间变异和批内变异分别为7.0 - 18.3%和3.8 - 7.5%。在脐带血和出生后的前4天，肾素浓度（几何平均值）显著高于较大婴儿和儿童（P < 0.05）[脐带血：155.2 mU/l；新生儿（出生2 - 4天）：90.9；新生儿（出生5 - 7天）：32.5；2周 - 3个月：40.8；4个月 - 1岁：54.5；1 - 3岁：46.3；3 - 5岁：48.5；5 - 7岁：51.6；7 - 11岁：38.5；11 - 15岁：37.7；15 - 18岁：31.9]。剖宫产出生的新生儿脐带血肾素浓度显著低于阴道分娩的新生儿（P < 0.02）。考虑到血浆肾素活性和肾素浓度测定方法的优缺点，肾素测量至少与血浆肾素活性测定一样有价值且准确。
