Ohyama K, Ohta M, Nakagomi Y, Yamori T, Fujimoto M, Amemiya S, Kato K
Department of Pediatrics, Yamanashi Medical College, Japan.
Horm Res. 1990;33(5):166-70. doi: 10.1159/000181503.
Plasma active and inactive renin concentrations (PARC and PIRC) were measured by immunoradiometric assay. Age-related changes in PARC, PIRC and the ratio of PARC/PIRC were studied in 78 normal children, age 1 month to 15 years. The effects of upright position for 15 min were also investigated in 7 postmenarcheal girls. PARC and PIRC in infants were significantly higher than in older children and their ratio of PARC/PIRC was significantly lower than in prepubertal children. During puberty, PARC, PIRC and their ratio were higher in premenarcheal girls than in postmenarcheal girls. In the upright position, PARC, PIRC and the ratio were increased significantly. These finding suggest that: (1) the production of inactive renin is increased but the activation of renin may be lowered in infants; (2) the activation of renin is affected by the menstrual cycle, and (3) the production and activation of renin are increased during short term standing.
采用免疫放射分析法测定血浆活性肾素和非活性肾素浓度（PARC和PIRC）。研究了78名1个月至15岁正常儿童中PARC、PIRC以及PARC/PIRC比值的年龄相关变化。还对7名初潮后女孩进行了15分钟直立位影响的研究。婴儿的PARC和PIRC显著高于大龄儿童，且其PARC/PIRC比值显著低于青春期前儿童。青春期期间，初潮前女孩的PARC、PIRC及其比值高于初潮后女孩。在直立位时，PARC、PIRC及其比值显著升高。这些发现表明：（1）婴儿中非活性肾素的产生增加，但肾素的激活可能降低；（2）肾素的激活受月经周期影响；（3）短期站立期间肾素的产生和激活增加。
