Ohyama K, Ohta M, Fujimoto M, Nakagomi Y, Yamori T, Kato K
Department of Pediatrics, Yamanashi Medical College, Japan.
Endocrinol Jpn. 1989 Aug;36(4):605-10. doi: 10.1507/endocrj1954.36.605.
In normal children aged one month to 16 years, the plasma active renin concentration (PARC) was measured with a renin immunoradiometricassay (IRMA) kit, and was compared with plasma renin activity (PRA). The IRMA for renin was found to be independent of the amount of renin substrate and not affected by the dilution of plasma samples, and was therefore proved to be a simple and reliable method. PRA measured in non-diluted plasma samples correlated well with PARC. In the age-related change, PARC in infants was significantly higher than that in older children. In infants, PARC was markedly higher in the crying state than that in the non-crying state. In normal children aged 7 to 11 years, PARC was significantly increased in the upright position compared to the supine position. These findings suggest that a hyperresponse of PARC to acute stress during blood sampling may cause an increase in active renin secretion in infants, and that stimulation by short-term standing may accelerate the activation of inactive renin or the release of active renin.
采用肾素免疫放射分析（IRMA）试剂盒对1个月至16岁正常儿童的血浆活性肾素浓度（PARC）进行测定，并与血浆肾素活性（PRA）进行比较。结果发现，肾素IRMA不受肾素底物量的影响，也不受血浆样本稀释的影响，因此被证明是一种简单可靠的方法。在未稀释血浆样本中测得的PRA与PARC相关性良好。在年龄相关变化方面，婴儿的PARC显著高于大龄儿童。婴儿在哭闹状态下的PARC明显高于非哭闹状态。在7至11岁的正常儿童中，与仰卧位相比，直立位时PARC显著升高。这些发现表明，采血过程中PARC对急性应激的高反应可能导致婴儿活性肾素分泌增加，短期站立刺激可能加速无活性肾素的激活或活性肾素的释放。
