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放血如何影响高谷胱甘肽和低谷胱甘肽绵羊的红细胞代谢。

How phlebotomy affects the erythrocyte metabolism of high- and low-glutathione sheep.

作者信息

Smith J E, Lee M

出版信息

Res Vet Sci. 1976 Sep;21(2):127-31.

PMID:968180
Abstract

Erythrocyte glutathione concentration increases dramatically in low-glutathione sheep of the Finnish-Landrace breed. To determine if this phenomenon occurs in low-glutathione sheep of the Corriedale or Merino type, the packed cell volume was decreased to less than 16 by phlebotomy. Glutathione concentrations increased in high- and low-glutathione sheep. Low-glutathione sheep returned to pre-phlebotomy levels by the 18th day; high-glutathione sheep increased, then decreased below pre-phlebotomy levels for the duration of the experiment. Packed cell volumes increased linearly (1-07 per cent per day) for 19 days. The maximum reticulocyte percentage (11-4) occurred on the eight day. Some erythrocyte enzymes increased as the mean cell age decreased, but some did not change. Erythrocyte adenosine-5'-triphosphate and creatine appear to be related to the reticulocyte count.

摘要

芬兰长白品种低谷胱甘肽绵羊的红细胞谷胱甘肽浓度会显著增加。为了确定这种现象是否也发生在考力代或美利奴类型的低谷胱甘肽绵羊中,通过放血使红细胞压积降至低于16%。高谷胱甘肽和低谷胱甘肽绵羊的谷胱甘肽浓度均升高。低谷胱甘肽绵羊在第18天恢复到放血前水平;高谷胱甘肽绵羊则先升高,然后在实验期间降至放血前水平以下。红细胞压积在19天内呈线性增加(每天1.07%)。最大网织红细胞百分比(11.4%)出现在第8天。随着平均细胞年龄的降低,一些红细胞酶增加,但有些则没有变化。红细胞腺苷-5'-三磷酸和肌酸似乎与网织红细胞计数有关。

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