Yoo K Y, Kim H, Shin H R, Kang D, Ha M, Park S K, Lee B O, Cho S H
Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
J Korean Med Sci. 1998 Jun;13(3):241-6. doi: 10.3346/jkms.1998.13.3.241.
A cross-sectional study was conducted to evaluate the relationship between body mass and serum level of female sex hormones among 153 adolescent girls, and 153 postmenopausal women in Korea. Information on lifestyles, and both menstrual and reproductive factors was collected by personal interview. Serum total estradiol (E2), progesterone (Pg), and sex hormone binding globulin (SHBG) concentrations were measured by radioimmunoassay. Multiple linear regression analysis was used to determine whether the hormonal levels would be affected by the obesity indices. Body weight and body mass index (BMI) were inversely related to SHBG level in both premenopausal (p<0.005) and postmenopausal women (p<0.005) after adjusting for age. E2 levels during any phase in premenopausal girls were not related to BMI, whereas heavier girls had significantly higher levels of late luteal-phase Pg (p<0.05). Taller postmenopausal women had lower E2 levels (p<0.05). Results on the association between SHBG and BMI are consistent with previous results in Caucasian women, and might suggest the potential role of bioavailable estradiol in breast carcinogenesis in pre- and post-menopausal women. The finding that progesterone might be related to body mass in premenopausal women should be pursued in further studies.
在韩国的153名青春期女孩和153名绝经后女性中开展了一项横断面研究，以评估体重与女性性激素血清水平之间的关系。通过个人访谈收集生活方式、月经和生殖因素方面的信息。采用放射免疫分析法测定血清总雌二醇（E2）、孕酮（Pg）和性激素结合球蛋白（SHBG）浓度。运用多元线性回归分析来确定激素水平是否会受到肥胖指数的影响。在调整年龄后，绝经前女性（p<0.005）和绝经后女性（p<0.005）的体重和体重指数（BMI）均与SHBG水平呈负相关。绝经前女孩任何阶段的E2水平均与BMI无关，而体重较重的女孩黄体晚期的Pg水平显著较高（p<0.05）。绝经后女性身高较高者E2水平较低（p<0.05）。SHBG与BMI之间关联的结果与之前白种女性的研究结果一致，这可能提示生物可利用雌二醇在绝经前和绝经后女性乳腺癌发生中的潜在作用。绝经前女性中孕酮可能与体重相关这一发现应在进一步研究中深入探讨。
