Tanaka J, Yamashita M, Yamashita M, Matsuo H, Yamamoto T
Department of Emergency and Critical Care Medicine, Hidaka Hospital, Gunma, Japan.
Vet Hum Toxicol. 1998 Aug;40(4):219-22.
Glufosinate ammonium (GLA), the active ingredient in the non-selective herbicide BASTA (18.5% GLA), is a phosphinic acid analogue of glutamic acid. We report 2 cases of GLA poisoning with late onset convulsions and increased serum CK in spite of low blood concentrations of GLA after hemodialysis. A 69-y-old female was admitted to the emergency department after taking 500 ml of BASTA. On arrival she was conscious, and gut decontamination, hemodialysis and hemoperfusion were performed. However, 8 1/2 hours after ingestion, general convulsions occurred. Her serum OK increased to a peak of 24,900 IU/L on the third day of admission. An 87-y-old male was admitted to the emergency department 3 1/2 hours after taking 200 ml of BASTA and receiving gastric lavage at a local emergency room. On arrival he was conscious, and serial activated charcoal and hemodialysis was performed. Blood concentration of GLA after hemodialysis decreased from 1.56 micrograms/ml to 0.68 micrograms/ml. Thirty hours after admission he had general convulsions. GLA was not detected in the cerebrospinal fluid 6 h after the convulsions. His serum CK increased to a peak of 17,870 IU/L on the fifth day of admission.
草铵膦铵盐（GLA）是非选择性除草剂“农达”（含18.5% GLA）中的活性成分，是谷氨酸的次膦酸类似物。我们报告了2例GLA中毒病例，尽管血液透析后血液中GLA浓度较低，但仍出现迟发性惊厥且血清肌酸激酶（CK）升高。一名69岁女性在服用500毫升“农达”后被送往急诊科。入院时她神志清醒，进行了胃肠道去污、血液透析和血液灌流。然而，摄入后8个半小时，出现全身惊厥。入院第三天，她的血清CK升至峰值24900 IU/L。一名87岁男性在服用200毫升“农达”并在当地急诊室接受洗胃后3个半小时被送往急诊科。入院时他神志清醒，进行了连续活性炭治疗和血液透析。血液透析后GLA血液浓度从1.56微克/毫升降至0.68微克/毫升。入院30小时后他出现全身惊厥。惊厥后6小时脑脊液中未检测到GLA。入院第五天，他的血清CK升至峰值17870 IU/L。
